Vedrop

Product Overview

About Vedrop

Vedrop is a medicine used to treat or prevent vitamin E deficiency (low vitamin E levels).

What it is used for

Vedrop is used in children up to the age of 18 years who have congenital or hereditary chronic cholestasis and who cannot absorb vitamin E from the gut. Congenital or hereditary chronic cholestasis is an inherited disease causing problems with the flow of bile from the liver to the gut. Bile is a fluid produced in the liver that helps to absorb fats from the gut.

How it is used

Vedrop can only be obtained with a prescription and treatment should be started and supervised by a doctor who has experience in treating patients with congenital or hereditary chronic cholestasis. Vedrop is available as a solution to be given by mouth. The recommended daily dose is 0.34 ml per kilogram body weight. This dose should be adjusted according to the amount of vitamin E in the patient’s blood. This should be checked regularly.

How it works

Vitamin E is a natural substance that cannot be made by the body and is therefore needed in the diet. It has a number of actions in the body, including protecting the nervous system from damage. Because vitamin E dissolves in fats but not in water, it can only be absorbed from the gut into the body alongside fat particles. Patients with cholestasis may have low vitamin E levels because they have problems absorbing fats from the gut. The active substance in Vedrop, tocofersolan, is vitamin E that has been made water soluble by attaching it to a chemical called polyethylene glycol. Tocofersolan can be absorbed from the gut in children who have difficulty absorbing fats and vitamin E from the diet. This can increase vitamin E levels in the blood and help to prevent damage to the nervous system due to vitamin E deficiency.

Active substance: Tocofersolan

Source: EMA EPAR