Voxzogo
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Active Ingredient: vosoritide
Product Overview
About Voxzogo
Voxzogo is a medicine that can only be obtained with a prescription.
How it is used
Treatment with Voxzogo must be started and supervised by a doctor experienced in the treatment of growth disorders or abnormal growth of bones. Voxzogo is given as an injection under the skin once a day, preferably around the same time of day. The site of injection should be changed with each injection. The recommended dose is calculated according to the patient’s body weight. Treatment should only be started when achondroplasia is confirmed by genetic testing and should end when the patient is not likely to grow any further. Voxzogo injections can be given by the patients’ caregiver once they have been trained appropriately.
How it works
In patients with achondroplasia, the FGFR3 gene, which regulates growth, is permanently 'switched on'. This prevents normal growth of bones, leading to bones that are shorter than normal. The active substance in Voxzogo, vosoritide, works by binding to a receptor (target) called natriuretic peptide receptor type B (NPR-B), which reduces the activity of FGFR3. This stimulates growth of bones, thereby improving the symptoms of the disease.
Active substance: vosoritide
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