Zinplava

Product Overview

About Zinplava

Zinplava is a medicine used in adults and children from one year of age who have infections due to bacteria called Clostridioides difficile that cause severe diarrhoea.

What it is used for

Zinplava is used to prevent future episodes of diarrhoea in patients who are taking antibiotics to treat their C. difficile infection and who are at high risk of the infection coming back.

How it is used

Zinplava is given as a single infusion (drip) into a vein lasting around 1 hour. The dose depends on the patient’s bodyweight. The medicine can only be obtained with a prescription.

How it works

C. difficile bacteria produce toxins that damage the lining of the gut causing diarrhoea which may be severe. After an initial infection, some dormant forms of the bacteria (spores) may persist in the body and eventually produce further toxins, causing the symptoms to return. The active substance in Zinplava, bezlotoxumab, is a monoclonal antibody (a type of protein) that has been designed to attach to these toxins, blocking their action, thereby preventing further damage and diarrhoea from occurring.

Active substance: bezlotoxumab

Source: EMA EPAR