Actraphane

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About Actraphane

Actraphane is a suspension for injection that contains the active substance human insulin. It is available as vials, cartridges (Penfill) or prefilled pens (InnoLet or FlexPen). Actraphane contains both fast-acting (soluble) and long-acting (isophane) insulin.

What it is used for

Actraphane is used to treat diabetes. The medicine can only be obtained with a prescription.

How it is used

Actraphane is given by injection under the skin in the thigh, the abdominal wall (at the front of the waist), the gluteal region (buttocks) or the deltoid region (shoulder). The injection site should be changed for each injection. The patient's blood glucose (sugar) should be tested regularly to find the lowest effective dose. The usual dose is between 0.3 and 1.0 international units (IU) per kilogram body weight per day. Actraphane is given 30 minutes before a meal. It is usually given once or twice a day when a rapid initial effect together with a more long-lasting effect is needed.

How it works

Diabetes is a disease in which the body does not produce enough insulin to control the blood glucose or when the body is unable to use insulin effectively. Actraphane is a replacement insulin which is very similar to the insulin made by the pancreas. The active substance in Actraphane, human insulin, is produced by a method known as ‘recombinant technology’: the insulin is made by yeast cells into which a gene (DNA) has been introduced, which makes them able to produce insulin. Actraphane contains insulin in two forms: a soluble form, which acts quickly (within 30 minutes of injection) and an isophane form, which is absorbed much more slowly during the day. This gives Actraphane a longer duration of action. The replacement insulin acts in the same way as naturally produced insulin and helps glucose enter cells from the blood. By controlling the blood glucose, the symptoms and complications of diabetes are reduced.

Active substance: human insulin

Source: EMA EPAR