PROGRAF
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Active Ingredient: TACROLIMUS
Product Overview
About PROGRAF
PROGRAF is a prescription medication containing the active ingredient Tacrolimus, a calcineurin inhibitor. It is used to prevent the rejection of transplanted organs in patients with a history of kidney or liver transplantation.
Key Benefits & Uses
- Prevention of organ rejection in kidney transplant patients
- Prevention of organ rejection in liver transplant patients
- Reduction of the risk of graft failure and improved patient survival
Active Ingredient & Action
Tacrolimus works by suppressing the immune system's response to the transplanted organ, thereby preventing rejection. It binds to the immunophilin FKBP-12, forming a complex that inhibits calcineurin, a protein phosphatase involved in the activation of T-lymphocytes. This leads to a decrease in the production of interleukin-2, a cytokine that promotes T-cell proliferation and activation.
Important Notes
PROGRAF should only be used under the guidance of a healthcare professional and as part of a comprehensive immunosuppressive regimen. Patients should be closely monitored for signs of organ rejection, such as fever, fatigue, and decreased kidney function. Regular blood tests are necessary to monitor tacrolimus levels and adjust the dosage accordingly. Common side effects of PROGRAF include tremors, headache, and nausea.
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