Cholib
Analogs of Cholib
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Active Ingredient: fenofibrate;simvastatin
Product Overview
About Cholib
Cholib is a medicine for improving blood fat levels.
What it is used for
Cholib is used together with a low-fat diet and exercise with the aim of reducing patients’ levels of triglycerides (a type of fat) and increasing their levels of ‘good’ cholesterol (high-density-lipoprotein [HDL] cholesterol). It is to be used in adults at high risk of heart disease whose levels of ‘bad’ cholesterol (low-density-lipoprotein [LDL] cholesterol) are already being controlled with the corresponding dose of simvastatin alone.
How it is used
Before starting treatment with Cholib, possible causes of the abnormal levels of blood fats should be adequately treated and patients should be placed on a standard fat-lowering diet. Cholib can only be obtained with a prescription and is available as tablets (145 / 20 mg and 145 / 40 mg). The recommended dose is one tablet a day to be swallowed whole with a glass of water. Grapefruit juice should be avoided during Cholib treatment as this is known to alter the amount of simvastatin in the blood.
How it works
The active substances in Cholib, fenofibrate and simvastatin, work in different ways and their actions have a complementary effect. Fenofibrate is a ‘PPARa agonist’. This means that it activates a type of receptor called the ‘peroxisome proliferator-activated receptor alpha’ (PPARa), which is involved in breaking down fats from diet, especially triglycerides. When these receptors are activated, the breakdown of fats speeds up, which helps clear the blood of ‘bad’ cholesterol and triglycerides. The second active substance, simvastatin, belongs to the group called ‘statins’. It reduces total blood cholesterol by blocking the action of 3-hydroxy-3-methyl-glutaryl-co-enzyme-A (HMG-CoA) reductase, an enzyme in the liver involved in the production of cholesterol.
Active substance: The active substances in Cholib are fenofibrate and simvastatin.
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