Vevzuo
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Active Ingredient: denosumab
Product Overview
About Vevzuo
Vevzuo is a solution for injection under the skin.
What it is used for
Vevzuo is used to prevent bone complications in cancer that has spread to the bone and in patients with giant cell tumour of bone.
How it is used
Vevzuo can only be obtained with a prescription. It is available as a solution for injection under the skin in the thigh, belly or upper arm. To prevent bone complications in cancer that has spread to the bone, the medicine is given once every 4 weeks as a single injection under the skin. In patients with giant cell tumour of bone, it is injected under the skin once a week for 3 weeks, and then once every 4 weeks. Patients should take calcium and vitamin D supplements while being treated with Vevzuo.
How it works
The active substance in Vevzuo, denosumab, is a monoclonal antibody which has been designed to recognise and attach to a protein called RANKL. This protein activates osteoclasts, the cells in the body that are involved in breaking down bone tissue. By attaching to RANKL and blocking it, denosumab reduces the formation and activity of the osteoclasts. This reduces the loss of bone, making fractures and other serious bone complications less likely. RANKL is also involved in activating the osteoclast-like cells in giant cell tumour of bone. Treatment with denosumab therefore prevents them from growing and breaking down bone, allowing normal bone to replace the tumour.
Active substance: denosumab
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