Savene
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Active Ingredient: dexrazoxane hydrochloride
Product Overview
About Savene
Savene is a powder and diluent that are made up into a solution for infusion (drip into a vein). It contains the active substance dexrazoxane.
What it is used for
Savene is used to treat extravasation of anthracyclines (a group of anticancer medicines). Extravasation happens when an anticancer medicine that is normally injected into a vein leaks or is accidentally injected in the tissue surrounding the vein, where it can cause serious damage.
How it is used
Savene must be used under the supervision of a doctor who has experience in the use of anticancer medicines. The first infusion of Savene is given as soon as possible after the accident, and no later than six hours after it happened. Two further infusions are then given, one on day 2 and another on day 3, at the same time as the first infusion. The infusion should last between one and two hours, and be given at a site other than where the extravasation happened.
How it works
The active substance in Savene, dexrazoxane, is an antidote to anthracyclines. The way it works is not entirely clear, but may be linked to the way the medicine attaches to iron in the body to form a ‘chelate’ and to its effect on some enzymes, such as topoisomerase II. Together, these effects can reduce the amount of tissue damage caused by anthracycline extravasation.
Active substance: dexrazoxane
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