Hospira Leucovorin Calcium Injection, (Calcium folinate) USP 500 mg/50 mL vial

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About Hospira Leucovorin Calcium Injection, (Calcium folinate) USP 500 mg/50 mL vial

Hospira Leucovorin Calcium Injection, (Calcium folinate) USP 500 mg/50 mL vial is a sterile, preservative-free injectable solution designed for clinical use. This medication is supplied as a clear, colorless to pale yellow solution intended for intravenous or intramuscular administration. Each vial contains 500 mg of calcium folinate, which serves as a derivative of folic acid. It is manufactured to meet United States Pharmacopeia standards for quality and purity. This product is intended for use by healthcare professionals in a hospital or clinical setting to manage specific therapeutic requirements related to folate metabolism and chemotherapy protocols.

Key Benefits & Uses

• Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination.
• Administered as part of a therapeutic regimen to enhance the efficacy of fluorouracil in treating colorectal cancer.
• Indicated for the treatment of megaloblastic anemias due to a deficiency of folic acid when oral therapy is not feasible.

Active Ingredient & Action

The active ingredient is calcium folinate, a calcium salt of folinic acid. Unlike folic acid, this compound does not require reduction by the enzyme dihydrofolate reductase to participate in cellular metabolic pathways. It acts as a potent agent to rescue normal cells from the toxic effects of folic acid antagonists and supports DNA synthesis.

Important Notes

This medication must be administered under the direct supervision of a qualified physician. It is not intended for self-administration. Ensure the solution is inspected visually for particulate matter and discoloration prior to use. Store the vials according to the manufacturer's temperature specifications to maintain product integrity.