Insuman

उत्पाद अवलोकन

About Insuman

Insuman is a range of insulin-containing solutions and suspensions for injection. It is supplied in vials, cartridges, or prefilled disposable pens. The Insuman range is comprised of: Insuman Rapid, Insuman Infusat and Insuman Implantable, which are fast-acting insulin solutions containing soluble insulin; Insuman Basal, an intermediate-acting insulin suspension containing isophane insulin; Insuman Comb, which is available in various combinations of fast- and intermediate-acting insulins.

What it is used for

Insuman is used in patients with diabetes (type 1 and 2) who need treatment with insulin. Insuman Rapid can also be used for the treatment of hyperglycaemic coma (coma caused by too much blood glucose [sugar]) and ketoacidosis (high levels of ketones [acids] in the blood), and to control blood glucose before, during or after an operation. Insuman Implantable is used in adult patients with type-1 diabetes that cannot be controlled with insulin given under the skin and who often have episodes of, otherwise unexplained, hyper- or hypoglycaemia (high or low blood glucose levels). The medicine can only be obtained with a prescription.

How it is used

Insuman Rapid, Infusat, Basal and Comb are given by injection under the skin, generally in the abdominal wall (tummy) or the thigh, according to the doctor’s recommendations. The injection site is changed for each injection. The desired blood glucose levels, the type of Insuman to be used, and the dose and timing of injections are determined by the doctor for each patient individually, and are adjusted to suit the patient’s diet, physical activity and lifestyle. The patient’s blood glucose should be tested regularly to find the lowest effective dose. Insuman should be given before meals. See the package leaflet for exact timings. Insuman Rapid may also be given into a vein, but only in an intensive care unit or similar setting where the patient can be closely monitored. Insuman Infusat is specially prepared ready to be used as a continuous infusion under the skin using an external portable infusion pump. Insuman Implantable is given only by infusion into the abdominal cavity using a pump (Medtronic MiniMed implantable pump) that is implanted under the skin of the abdomen. Insuman Implantable must not be used in any other way and can only be used in centres where staff have received adequate training in the use of the implantable pump. Further information on the way Insuman is given can be found in the summary of product characteristics (also part of the EPAR).

How it works

Diabetes is a disease in which the body does not produce enough insulin to control the level of blood glucose (type-1 diabetes) or when the body is unable to use insulin effectively (type-2 diabetes). Insuman is a replacement insulin that is similar to the insulin made by the body. The active substance in Insuman, human insulin, is produced by a method known as ‘recombinant DNA technology’: it is made by bacteria into which a gene (DNA) has been introduced that makes the bacteria able to produce insulin. Insuman contains insulin in various forms: the soluble form, which acts quickly (within 30 minutes of injection), and the isophane and crystalline-protamine forms, which are absorbed much more slowly during the day, giving them a longer duration of action. The replacement insulin acts in the same way as naturally produced insulin and helps glucose enter cells from the blood. By controlling the level of blood glucose, the symptoms and complications of diabetes are reduced.

Active substance: human insulin

Source: EMA EPAR