СУЛЬФАСАЛАЗИН-ЕН

उत्पाद अवलोकन

About СУЛЬФАСАЛАЗИН-ЕН

СУЛЬФАСАЛАЗИН-ЕН — tablets, coated with an enteric-soluble coating, containing 500 mg of sulfasalazine. The package contains 50 tablets.

Composition

Active ingredient: sulfasalazine — 500 mg in 1 tablet. Excipients: povidone, pre-gelatinized starch, magnesium stearate, anhydrous colloidal silicon dioxide, titanium dioxide (E 171), yellow iron oxide (E 172), talc, triethyl citrate, macrogol 6000, sodium carboxymethylcellulose, and methacrylic acid copolymer type A.

Indications

The drug is used to treat mild and moderate ulcerative colitis, as an adjunct therapy for severe ulcerative colitis, and to prolong remission between acute attacks of the disease.

СУЛЬФАСАЛАЗИН-ЕН is prescribed to patients with rheumatoid arthritis if salicylates or other non-steroidal anti-inflammatory drugs were insufficiently effective, including due to insufficient therapeutic effect or intolerance. The drug is also used to treat juvenile rheumatoid arthritis with polyarticular syndrome in case of insufficient effectiveness of salicylates or other NSAIDs.

Pharmacological properties

Sulfasalazine accumulates in the connective tissue of the intestine and releases 5-aminosalicylic acid and sulfapyridine. 5-aminosalicylic acid has an anti-inflammatory effect, and sulfapyridine exhibits antimicrobial activity against diplococci, streptococci, gonococci, and intestinal bacillus.

The drug has an immunosuppressive effect, especially in connective tissue, intestinal wall, and serous fluid, where its concentration is highest. Sulfapyridine reduces systemic inflammation, exhibits antibacterial activity, inhibits the activity of natural killer cells, and transforms leukocytes.

The anti-inflammatory effect of 5-aminosalicylic acid is particularly important in inflammatory bowel diseases. It predominantly locally inhibits cyclooxygenase and lipooxygenase in the intestinal wall, which reduces the formation of prostaglandins, leukotrienes, and other mediators of inflammation. Low absorption contributes to reduced inflammation in the colon.

Source: Compendium